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Methadone
Synthetic narcotic , any of a number of substances that have a depressant effect on the nervous system. The chief narcotic drugs are opium , its constituents morphine and codeine , and the morphine derivative heroin.

Actions and Uses
Similar in effect to morphine, principal derivative of opium , which is the juice in the unripe seed pods of the opium poppy , Papaver somniferum. Given intravenously, it is still considered the most effective drug for the relief of pain.
It is sometimes used as an analgesic and to suppress the cough reflex.
In the brains of addicts, methadone prevents heroin, opiate drug synthesized from morphine . Originally produced in 1874, it was thought to be not only nonaddictive but useful as a cure for respiratory illness and morphine addiction, and capable of relieving morphine withdrawal symptoms.
Morphine from interacting with receptors for natural painkillers called endorphins endorphins  neurotransmitters found in the brain that have pain-relieving properties similar to morphine. There are three major types of endorphins: beta endorpins, found primarily in the pituitary gland; and enkephalins and dynorphin, both distributed throughout the nervous system.
Blocking the effects of the addictive drugs and reducing the physical cravings. In controlled doses it creates its own effects of mild euphoria and drowsiness, but lasts much longer (one to two days) and does not create the sometimes fatal respiratory depression that opiates do. Its continued use as a heroin substitute eventually restores sexual, immune, and adrenal function. When methadone is given to a heroin addict who is later withdrawn from methadone, the addict will undergo methadone withdrawal instead of the more severe heroin withdrawal.


Heroin opiate drug opiate drug, any of a group of drugs derived from opium . Used medicinally to relieve pain and induce sleep, they include codeine , morphine , the morphine derivative heroin , and, formerly, laudanum . Sometimes included in the group are certain synthetic drugs that have morphine like pharmacological action.
Synthesized from morphine morphine, principal derivative of opium , which is the juice in the unripe seed pods of the opium poppy , Papaver somniferum. It was first isolated from opium in 1803 by the German pharmacist F. W. A. Sertürner, who named it after Morpheus , the god of dreams. Given intravenously, it is still considered the most effective drug for the relief of pain.
Narcotic, any of a number of substances that have a depressant effect on the nervous system. The chief narcotic drugs are opium , its constituents morphine and codeine , and the morphine derivative heroin.


Effects and Addiction
Heroin is a central nervous system depressant that relieves pain and induces sleep. It produces a dreamlike state of warmth and well-being. It may also cause constricted pupils, nausea, and respiratory depression, which in its extremes can result in death. Heroin activates brain regions that produce euphoric sensations and brain regions that produce physical dependence—hence its notorious ability to produce both psychological and physical addiction.

Most heroin originates from opium poppy farms in SE Asia , SW Asia , and Latin American . The opium gum is converted to morphine in labs near the fields and then to heroin in labs within or near the producing country. After importation, drug dealers cut, or dilute, the heroin (1 part heroin to 9 to 99 parts dilutor) with sugars, starch, or powdered milk before selling it to addicts; quinine  white crystalline alkaloid with a bitter taste.
Also added to imitate the bitter taste of heroin so the addict cannot tell how much heroin is actually present. It is sold in single-dose bags of 0.1 gram (0.03 oz.), each costing between $10 and $50 . One pound of diluted heroin yields approximately 4,000 doses.




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